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Window Resolution and Sizing

I am struggling to get the resolution right on large monitors the one i am working on now is
3840 * 2160 with a Scale of 150% If i change the scale to 100% it doesn’t look right.
I have tried changing the compatibility settings as previously recommended but not right.
Also this project entails one large “Workstation” with a few smaller RV’s so I have to accommodate them also

Any Ideas?